Spatial distribution of CD3- and CD8-positive lymphocytes as pretest for POLE wild-type in molecular subgroups of endometrial carcinoma

Spatial distribution of CD3- and CD8-positive lymphocytes as pretest for POLE wild-type in molecular subgroups of endometrial carcinoma

IntroductionOver the years, the molecular classification of endometrial carcinoma has evolved significantly. Both POLEmut and MMRdef cases share tumor biological similarities like high tumor mutational burden and induce strong lymphatic reactions. While therefore use case scenarios for pretesting wi...

Full description

Bibliographic Details
Main Authors: Samuel H. Jungen, Luca Noti, Lucine Christe, Jose A. Galvan, Inti Zlobec, Michael D. Müller, Sara Imboden, Franziska Siegenthaler, Joseph W. Carlson, Teijo Pellinen, Victoria Heredia-Soto, Ignacio Ruz-Caracuel, David Hardisson, Andres Redondo, Marta Mendiola, Tilman T. Rau
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Medicine
Subjects:
endometrial carcinoma
TCGA
POLE
CD3
CD8
multiplex immunofluorescence
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1110529/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1110529/full

Similar Items