Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.

G3BP-1 and -2 (hereafter referred to as G3BP) are multifunctional RNA-binding proteins involved in stress granule (SG) assembly. Viruses from diverse families target G3BP for recruitment to replication or transcription complexes in order to block SG assembly but also to acquire pro-viral effects via...

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Bibliographic Details
Main Authors: Benjamin Götte, Marc D Panas, Kirsi Hellström, Lifeng Liu, Baila Samreen, Ola Larsson, Tero Ahola, Gerald M McInerney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007842

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https://doi.org/10.1371/journal.ppat.1007842

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