Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43

Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43

Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor effects. In this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma (HCC) cells (Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liv...

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Bibliographic Details
Main Authors: Yuri Cho, Jung-Hwan Yoon, Jeong-ju Yoo, Minjong Lee, Dong Hyeon Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim, Chung Yong Kim
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Fucoidan
Hepatocellular carcinoma
Invasion
Hypoxia
Hepatoprotective
Cultured hepatocyte
NDRG-1/CAP43
VMP-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515001367

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http://www.sciencedirect.com/science/article/pii/S2211383515001367

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