Prostate Cancer Cell-Derived Urokinase-Type Plasminogen Activator Contributes to Intraosseous Tumor Growth and Bone Turnover

Prostate Cancer Cell-Derived Urokinase-Type Plasminogen Activator Contributes to Intraosseous Tumor Growth and Bone Turnover

A variety of proteases have been implicated in prostate cancer (PC) bone metastasis, but the individual contributions of these enzymes remain unclear. Urokinase-type plasminogen activator (uPA), a serine protease, can activate plasminogen and stimulate signaling events on binding its receptor uPAR....

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Bibliographic Details
Main Authors: Zhong Dong, Allen D. Saliganan, Hong Meng, Sanaa M. Nabha, Aaron L. Sabbota, Shijie Sheng, R. Daniel Bonfil, Michael L. Cher
Format: Article
Language:English
Published: Elsevier 2008-05-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608800681

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http://www.sciencedirect.com/science/article/pii/S1476558608800681

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