The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal

Abstract Senescence, a state of irreversible cell-cycle withdrawal, is difficult to distinguish from quiescence, a state of reversible cell-cycle withdrawal. This difficulty arises because quiescent and senescent cells are defined by overlapping biomarkers, raising the question of whether these stat...

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Bibliographic Details
Main Authors: Humza M. Ashraf, Brianna Fernandez, Sabrina L. Spencer
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40132-0