Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis.

Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis.

Determine whether MS-specific DNA methylation profiles can be identified in whole blood or purified immune cells from untreated MS patients.Whole blood, CD4+ and CD8+ T cell DNA from 16 female, treatment naïve MS patients and 14 matched controls was profiled using the HumanMethylation450K BeadChip....

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Bibliographic Details
Main Authors: Steffan D Bos, Christian M Page, Bettina K Andreassen, Emon Elboudwarej, Marte W Gustavsen, Farren Briggs, Hong Quach, Ingvild S Leikfoss, Anja Bjølgerud, Tone Berge, Hanne F Harbo, Lisa F Barcellos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4348521?pdf=render

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http://europepmc.org/articles/PMC4348521?pdf=render

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