Prostate progenitor cells proliferate in response to castration

Androgen-deprivation is a mainstay of therapy for advanced prostate cancer but tumor regression is usually incomplete and temporary because of androgen-independent cells in the tumor. It has been speculated that these tumor cells resemble the stem/progenitor cells of the normal prostate. The purpose...

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Bibliographic Details
Main Authors: Xudong Shi, Jerry Gipp, Michael Dries, Wade Bushman
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506114000415