Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes <i>C1orf185</i> and <i>CCT6B</i>

Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes <i>C1orf185</i> and <i>CCT6B</i>

The genetic landscape of male infertility is highly complex. It is estimated that at least 4000 genes are involved in human spermatogenesis, but only few have so far been extensively studied. In this study, we investigated by whole exome sequencing two cases of idiopathic non-obstructive azoospermia...

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Bibliographic Details
Main Authors: Caroline Cazin, Yasmine Neirijnck, Corinne Loeuillet, Lydia Wehrli, Françoise Kühne, Isabelle Lordey, Selima Fourati Ben Mustapha, Amin Bouker, Raoudha Zouari, Nicolas Thierry-Mieg, Serge Nef, Christophe Arnoult, Pierre F. Ray, Zine-Eddine Kherraf
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
spermatogenesis
non-obstructive azoospermia
genetics of male infertility
whole exome sequencing
CRISPR/Cas9
<i>C1orf185</i>
Online Access:https://www.mdpi.com/2073-4409/11/1/118

Internet

https://www.mdpi.com/2073-4409/11/1/118

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