HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer

HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer

Background: The treatment of non-small-cell lung cancer (NSCLC) involves platinum-based chemotherapy. It is typically accompanied by chemoresistance resulting from antioxidant properties conferred by cancer stem cells (CSCs). Human epidermal growth factor receptor 2 (HER2) enhances CSCs and antioxid...

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Bibliographic Details
Main Authors: Kuang-Tai Kuo, Cheng-Hsin Lin, Chun-Hua Wang, Narpati Wesa Pikatan, Vijesh Kumar Yadav, Iat-Hang Fong, Chi-Tai Yeh, Wei-Hwa Lee, Wen-Chien Huang
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
non-small-cell lung cancer
cancer stem cells
human epidermal growth factor receptor 2
NRF2/HO-1/HER2 axis
HNMT/HER2’s role
Online Access:https://www.mdpi.com/1422-0067/23/3/1663

Internet

https://www.mdpi.com/1422-0067/23/3/1663

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