Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells

Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated molecular patterns and may induce valvular inflammation. Matrilin-2 is an ECM protein and has been found to elevate the pro-osteogenic activity...

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Bibliographic Details
Main Authors: Erlinda The, Qingzhou Yao, Peijian Zhang, Yufeng Zhai, Lihua Ao, David A. Fullerton, Xianzhong Meng
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/9/2/385