FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice

FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice

Abstract Alzheimer’s disease (AD) is the most common dementia. It is known that women with one ApoE4 allele display greater risk and earlier onset of AD compared with men. In mice, we previously showed that follicle–stimulating hormone (FSH), a gonadotropin that rises in post–menopausal females, act...

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Bibliographic Details
Main Authors: Jing Xiong, Seong Su Kang, Mengmeng Wang, Zhihao Wang, Yiyuan Xia, Jianming Liao, Xia Liu, Shan-Ping Yu, Zhaohui Zhang, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42282-7

Internet

https://doi.org/10.1038/s41467-023-42282-7

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