Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1

Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1

Abstract Background circRNA has been established to play a pivotal role in tumorigenesis development in a variety of cancers; nevertheless, the biological functions and molecular mechanisms of hypoxia-induced exosomal circRNAs in pancreatic cancer remain largely unknown. Methods Differentially expre...

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Bibliographic Details
Main Authors: Jiewei Lin, Xinjing Wang, Shuyu Zhai, Minmin Shi, Chenghong Peng, Xiaxing Deng, Da Fu, Jiancheng Wang, Baiyong Shen
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Hematology & Oncology
Subjects:
Hypoxia
Exosomes
Pancreatic cancer
circRNA
ceRNA
Ubiquitination
Online Access:https://doi.org/10.1186/s13045-022-01348-7

Internet

https://doi.org/10.1186/s13045-022-01348-7

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