Study of the anticancer effect of new quinazolinone hydrazine derivatives as receptor tyrosine kinase inhibitors

Study of the anticancer effect of new quinazolinone hydrazine derivatives as receptor tyrosine kinase inhibitors

The advent of novel receptor tyrosine kinase inhibitors has provided an important therapeutic tool for cancer patients. In this study, a series of quinazolinone hydrazide triazole derivatives were designed and synthesized as novel MET (c-MET) receptor tyrosine kinase inhibitors. The antiproliferativ...

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Bibliographic Details
Main Authors: Motahareh Mortazavi, Masoumeh Divar, Tahereh Damghani, Fatemeh Moosavi, Luciano Saso, Somayeh Pirhadi, Mehdi Khoshneviszadeh, Najmeh Edraki, Omidreza Firuzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Chemistry
Subjects:
anticancer agents
kinase inhibitors
multitargeted compounds
drug design
three-dimensional culture
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.969559/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.969559/full

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