Genetic regulation of RNA splicing in human pancreatic islets

Genetic regulation of RNA splicing in human pancreatic islets

Abstract Background Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however, the mechanisms through which non-coding variants...

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Main Authors: Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel J. M. Crouch, Javier Garcia-Hurtado, Ignasi Moran, the T2DSystems Consortium, Manuel Irimia, Rashmi B. Prasad, Anna L. Gloyn, Lorella Marselli, Mara Suleiman, Thierry Berney, Eelco J. P. de Koning, Julie Kerr-Conte, Francois Pattou, John A. Todd, Lorenzo Piemonti, Jorge Ferrer
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Genome Biology
Subjects:
RNA splicing
Type 1 diabetes
Type 2 diabetes
TWAS
G-protein signaling
Pancreatic islets
Online Access:https://doi.org/10.1186/s13059-022-02757-0

Internet

https://doi.org/10.1186/s13059-022-02757-0

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