An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag <subtitle>Short title: Controlled bioconjugation via O-glycan engineering</subtitle>

An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag <subtitle>Short title: Controlled bioconjugation via O-glycan engineering</subtitle>

Bioconjugates are an important class of therapeutic molecules. To date, O-glycan-based metabolic glycoengineering has had limited use in this field, due to the complexities of the endogenous O-glycosylation pathway and the lack of an O-glycosylation consensus sequence. Here, we describe the developm...

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Bibliographic Details
Main Authors: Thomas V. Murray, Kasia Kozakowska-McDonnell, Adam Tibbles, Annabel Taylor, Daniel Higazi, Emmanuel Rossy, Alessandra Rossi, Sivaneswary Genapathy, Giulia Tamburrino, Nicola Rath, Natalie Tigue, Vivian Lindo, Tristan Vaughan, Monika A. Papworth
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
O-glycosylation
metabolic labeling
CRISPR
metabolic glycoengineering
bioconjugation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2021.1992068

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2021.1992068

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