An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag <subtitle>Short title: Controlled bioconjugation via O-glycan engineering</subtitle>

An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag <subtitle>Short title: Controlled bioconjugation via O-glycan engineering</subtitle>

Bioconjugates are an important class of therapeutic molecules. To date, O-glycan-based metabolic glycoengineering has had limited use in this field, due to the complexities of the endogenous O-glycosylation pathway and the lack of an O-glycosylation consensus sequence. Here, we describe the developm...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Thomas V. Murray, Kasia Kozakowska-McDonnell, Adam Tibbles, Annabel Taylor, Daniel Higazi, Emmanuel Rossy, Alessandra Rossi, Sivaneswary Genapathy, Giulia Tamburrino, Nicola Rath, Natalie Tigue, Vivian Lindo, Tristan Vaughan, Monika A. Papworth
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: Taylor & Francis Group 2021-01-01
Σειρά:mAbs
Θέματα:
O-glycosylation
metabolic labeling
CRISPR
metabolic glycoengineering
bioconjugation
Διαθέσιμο Online:https://www.tandfonline.com/doi/10.1080/19420862.2021.1992068

Διαδίκτυο

https://www.tandfonline.com/doi/10.1080/19420862.2021.1992068

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