Predictive features of ligand‐specific signaling through the estrogen receptor

Predictive features of ligand‐specific signaling through the estrogen receptor

Abstract Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar activities in different cell types. To identify biophysical determinants of cell‐specific signaling and breast cancer cell prolifera...

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Bibliographic Details
Main Authors: Jerome C Nwachukwu, Sathish Srinivasan, Yangfan Zheng, Song Wang, Jian Min, Chune Dong, Zongquan Liao, Jason Nowak, Nicholas J Wright, René Houtman, Kathryn E Carlson, Jatinder S Josan, Olivier Elemento, John A Katzenellenbogen, Hai‐Bing Zhou, Kendall W Nettles
Format: Article
Language:English
Published: Springer Nature 2016-04-01
Series:Molecular Systems Biology
Subjects:
Breast cancer
Chemical biology
Crystal structure
Nuclear receptor
Signal transduction
Online Access:https://doi.org/10.15252/msb.20156701

Internet

https://doi.org/10.15252/msb.20156701

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