Differential effect of lactate on synovial fibroblast and macrophage effector functions

Differential effect of lactate on synovial fibroblast and macrophage effector functions

IntroductionThe synovial membrane is the main site of inflammation in rheumatoid arthritis (RA). Here several subsets of fibroblasts and macrophages, with distinct effector functions, have been recently identified. The RA synovium is hypoxic and acidic, with increased levels of lactate as a result o...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Valentina Pucino, Meriam Nefla, Vincent Gauthier, Ghada Alsaleh, Sally A. Clayton, Jennifer Marshall, Andrew Filer, Andy R. Clark, Karim Raza, Christopher D. Buckley
Format: Artykuł
Język:English
Wydane: Frontiers Media S.A. 2023-05-01
Seria:Frontiers in Immunology
Hasła przedmiotowe:
lactate
fibroblasts
macrophages
arthritis
cell metabolism
Dostęp online:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183825/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183825/full

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