Differential effect of lactate on synovial fibroblast and macrophage effector functions

Differential effect of lactate on synovial fibroblast and macrophage effector functions

IntroductionThe synovial membrane is the main site of inflammation in rheumatoid arthritis (RA). Here several subsets of fibroblasts and macrophages, with distinct effector functions, have been recently identified. The RA synovium is hypoxic and acidic, with increased levels of lactate as a result o...

Full description

Bibliographic Details
Main Authors: Valentina Pucino, Meriam Nefla, Vincent Gauthier, Ghada Alsaleh, Sally A. Clayton, Jennifer Marshall, Andrew Filer, Andy R. Clark, Karim Raza, Christopher D. Buckley
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
lactate
fibroblasts
macrophages
arthritis
cell metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183825/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183825/full

Similar Items