Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells

Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells

Chronic liver injury causes fibrosis, characterized by the formation of scar tissue resulting from excessive accumulation of extracellular matrix (ECM) proteins. Hepatic stellate cell (HSC) myofibroblasts are the primary cell type responsible for liver fibrosis, yet there are currently no therapies...

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Bibliographic Details
Main Authors: Wenyang Li, Jennifer Y Chen, Cheng Sun, Robert P Sparks, Lorena Pantano, Raza-Ur Rahman, Sean P Moran, Joshua V Pondick, Rory Kirchner, David Wrobel, Michael Bieler, Achim Sauer, Shannan J Ho Sui, Julia F Doerner, Jörg F Rippmann, Alan C Mullen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
nanchangmycin
liver fibrosis
hepatic stellate cells
compound screening
FYN
collagen
Online Access:https://elifesciences.org/articles/74513

Internet

https://elifesciences.org/articles/74513

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