Influence of Genetic Variation in <i>COMT</i> on Cisplatin-Induced Nephrotoxicity in Cancer Patients

Influence of Genetic Variation in <i>COMT</i> on Cisplatin-Induced Nephrotoxicity in Cancer Patients

Cisplatin is a chemotherapeutic agent widely used for multiple indications. Unfortunately, in a substantial set of patients treated with cisplatin, dose-limiting acute kidney injury (AKI) occurs. Here, we assessed the association of 3 catechol-O-methyltransferase (<i>COMT)</i> single nuc...

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Bibliographic Details
Main Authors: Bram C. Agema, Stijn L.W. Koolen, Mirjam de With, Nadia van Doorn, Niels Heersche, Esther Oomen-de Hoop, Sabine Visser, Joachim G.J.V. Aerts, Sander Bins, Ron H.N. van Schaik, Ron H.J. Mathijssen
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Genes
Subjects:
cisplatin
acute kidney injury
<i>COMT</i>
nephrotoxicity
SNP
Online Access:https://www.mdpi.com/2073-4425/11/4/358

Internet

https://www.mdpi.com/2073-4425/11/4/358

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