HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction

HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction

Abstract Background This study aimed to investigate the role of histone deacetylase 5 (HDAC5) in ventricular remodeling and explore the therapeutic potential of the HDAC5 inhibitor LMK235. Methods A transverse aortic constriction (TAC) mouse model and angiotensin II (Ang II)-treated H9C2 cells were...

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Bibliographic Details
Main Authors: Chenxi Zhu, Zhehao Piao, Li Jin
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Orphanet Journal of Rare Diseases
Subjects:
HDAC5
Cardiac hypertrophy
EGR1
MEF2A
Therapies
Online Access:https://doi.org/10.1186/s13023-023-02896-y

Internet

https://doi.org/10.1186/s13023-023-02896-y

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