Replication Stress: A Review of Novel Targets to Enhance Radiosensitivity-From Bench to Clinic

Replication Stress: A Review of Novel Targets to Enhance Radiosensitivity-From Bench to Clinic

DNA replication is a process fundamental in all living organisms in which deregulation, known as replication stress, often leads to genomic instability, a hallmark of cancer. Most malignant tumors sustain persistent proliferation and tolerate replication stress via increasing reliance to the replica...

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Bibliographic Details
Main Authors: Yuewen Zhang, Lei Wu, Zhao Wang, Jinpeng Wang, Shrabasti Roychoudhury, Bartlomiej Tomasik, Gang Wu, Geng Wang, Xinrui Rao, Rui Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
replication stress
DNA damage repair
radiation therapy
radioresistance
radiosensitizer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.838637/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.838637/full

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