Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach

Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach

Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by a sustained elevation of pulmonary artery (PA) pressure, right ventricular failure, and premature death. Enhanced proliferation and resistance to apoptosis (as seen in cancer cells) of PA smooth muscle cells (PASMCs) is...

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Bibliographic Details
Main Authors: Karima Habbout, Junichi Omura, Charifa Awada, Alice Bourgeois, Yann Grobs, Vinod Krishna, Sandra Breuils-Bonnet, Eve Tremblay, Ghada Mkannez, Sandra Martineau, Valérie Nadeau, Florence Roux-Dalvai, Mark Orcholski, Jey Jeyaseelan, David Gutstein, François Potus, Steeve Provencher, Sébastien Bonnet, Roxane Paulin, Olivier Boucherat
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
vascular remodeling
epigenetics
metabolism
right ventricle
Online Access:https://www.mdpi.com/1422-0067/22/6/2957

Internet

https://www.mdpi.com/1422-0067/22/6/2957

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