Extended N-Arylsulfonylindoles as 5-HT6 Receptor Antagonists: Design, Synthesis & Biological Evaluation

Extended N-Arylsulfonylindoles as 5-HT6 Receptor Antagonists: Design, Synthesis & Biological Evaluation

Based on a known pharmacophore model for 5-HT6 receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT6 receptor modulators. Eight of the compounds exhibited moderate to high binding affinities and displayed...

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Bibliographic Details
Main Authors: Gonzalo Vera, Carlos F. Lagos, Sebastián Almendras, Dan Hebel, Francisco Flores, Gissella Valle-Corvalán, C. David Pessoa-Mahana, Jaime Mella-Raipán, Rodrigo Montecinos, Gonzalo Recabarren-Gajardo
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Molecules
Subjects:
arylsulfonylindole
5-HT6 receptor antagonists
binding affinity
arylpiperazines
Online Access:http://www.mdpi.com/1420-3049/21/8/1070

Internet

http://www.mdpi.com/1420-3049/21/8/1070

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