Extended N-Arylsulfonylindoles as 5-HT6 Receptor Antagonists: Design, Synthesis & Biological Evaluation
Based on a known pharmacophore model for 5-HT6 receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT6 receptor modulators. Eight of the compounds exhibited moderate to high binding affinities and displayed...
| Main Authors: | , , , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
MDPI AG
2016-08-01
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| 叢編: | Molecules |
| 主題: | |
| 在線閱讀: | http://www.mdpi.com/1420-3049/21/8/1070 |