Pharmacological inhibition of protein tyrosine kinases axl and fyn reduces TNF-α-induced endothelial inflammatory activation in vitro

Pharmacological inhibition of protein tyrosine kinases axl and fyn reduces TNF-α-induced endothelial inflammatory activation in vitro

Major surgery induces systemic inflammation leading to pro-inflammatory activation of endothelial cells. Endothelial inflammation is one of the drivers of postoperative organ damage, including acute kidney injury Tumour Necrosis Factor alpha (TNF-α) is an important component of surgery-induced pro-i...

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Bibliographic Details
Main Authors: Sophie F. Ellermann, Rianne M. Jongman, Matthijs Luxen, Timara Kuiper, Josee Plantinga, Jill Moser, Thomas W. L. Scheeren, Gregor Theilmeier, Grietje Molema, Matijs Van Meurs
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
endothelial inflammation
tumour necrosis factor alpha (TNF-α)
postoperative organ damage
kinases
axl
fyn
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.992262/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.992262/full

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