Genes of ancient microtubule-stabilizing proteins traveled through pre-Cambrian Echinoidea to advanced life forms of dry land and ended up in the human genome as the fusion oncogenes-oncoproteins eml1/EML1-abl/ABL, and eml4/EML4-alk/ALK
The genes eml1/4 of the Echinodermata microtubule-stabilizing gene product-like 1/4 proteins EML1/4 of the sea cucumbers (Holothuroidea) traveled through the evolutionary scale up to the human genome. Human cells malignantly transformed by oncogenes abl or alk enlist the protein products EML1/4 f...
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| Format: | Article |
| Language: | English |
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University of Modena and Reggio Emilia
2016-03-01
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| Series: | Invertebrate Survival Journal |
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| Online Access: | http://www.isj.unimo.it/articoli/ISJ414.pdf |