Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes

Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes

Abstract Background Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Multiple laboratory findings indicate that calcitriol may be a potential...

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Bibliographic Details
Main Authors: Ting-Wei Lee, Ting-I Lee, Yung-Kuo Lin, Yu-Hsun Kao, Yi-Jen Chen
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Biomedical Science
Subjects:
Calcitriol
Cardiomyocyte
Fibroblast growth factor receptor
Histone deacetylase
Vitamin D
Online Access:http://link.springer.com/article/10.1186/s12929-018-0443-3

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http://link.springer.com/article/10.1186/s12929-018-0443-3

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