Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study

Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study

Abstract Background Antimalarial efficacy studies in patients with uncomplicated Plasmodium falciparum are confounded by a new infection (a competing risk event) since this event can potentially preclude a recrudescent event (primary endpoint of interest). The current WHO guidelines recommend censor...

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Detaylı Bibliyografya
Asıl Yazarlar: Prabin Dahal, Philippe J. Guerin, Ric N. Price, Julie A. Simpson, Kasia Stepniewska
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: BMC 2019-05-01
Seri Bilgileri:BMC Medical Research Methodology
Konular:
Malaria
Plasmodium falciparum
Efficacy
Competing risk events
Cumulative incidence function
Online Erişim:http://link.springer.com/article/10.1186/s12874-019-0748-2

Internet

http://link.springer.com/article/10.1186/s12874-019-0748-2

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