Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study

Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study

Abstract Background Antimalarial efficacy studies in patients with uncomplicated Plasmodium falciparum are confounded by a new infection (a competing risk event) since this event can potentially preclude a recrudescent event (primary endpoint of interest). The current WHO guidelines recommend censor...

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Bibliographic Details
Main Authors: Prabin Dahal, Philippe J. Guerin, Ric N. Price, Julie A. Simpson, Kasia Stepniewska
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Medical Research Methodology
Subjects:
Malaria
Plasmodium falciparum
Efficacy
Competing risk events
Cumulative incidence function
Online Access:http://link.springer.com/article/10.1186/s12874-019-0748-2

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