Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate

Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate

WIZ (Widely Interspaced Zinc Finger) is associated with the G9a-GLP protein complex, a key H3K9 methyltransferase suggesting a role in transcriptional repression. However, its role in embryonic development is poorly described. In order to assess the loss of function of WIZ, we generated CRISPR/Cas9...

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Bibliographic Details
Main Authors: Ivana Bukova, Katarzyna Izabela Szczerkowska, Michaela Prochazkova, Inken M. Beck, Jan Prochazka, Radislav Sedlacek
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Wiz
G9a/GLP
histone methylation
cleft palate
development
craniofacial
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.620692/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.620692/full

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