TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.

TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.

TDP-43 is a multifunctional nucleic acid binding protein linked to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia. To learn more about the normal biological and abnormal pathological role of this protein, we turned to Caenorhabditis elega...

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Bibliographic Details
Main Authors: Alexandra Vaccaro, Arnaud Tauffenberger, Peter E A Ash, Yari Carlomagno, Leonard Petrucelli, J Alex Parker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3390363?pdf=render

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http://europepmc.org/articles/PMC3390363?pdf=render

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