Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

IntroductionInfants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions.MethodsIn this study, we evaluated Fc receptor engagement and ADCC activity of plas...

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Bibliographic Details
Main Authors: Brittani M. Barrows, Shelly J. Krebs, Ningbo Jian, Michelle Zemil, Bonnie M. Slike, Vincent Dussupt, Ursula Tran, Letzibeth Mendez-Rivera, David Chang, Anne Marie O’Sullivan, Brendan Mann, Eric Sanders-Buell, Zhanna Shubin, Matt Creegan, Dominic Paquin-Proulx, Philip Ehrenberg, Agnes Laurence-Chenine, Kriengkrai Srithanaviboonchai, Rasmi Thomas, Michael A. Eller, Guido Ferrari, Merlin Robb, Venigalla Rao, Sodsai Tovanabutra, Victoria R. Polonis, Lindsay Wieczorek
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
vertical transmission
antibody dependent cellular cytotoxicity
neonatal Fc receptor
passive immunity
CRF01_AE HIV
Thailand
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051501/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051501/full

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