A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough

A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough

Objective Baclofen is a centrally acting γ-aminobutyric acid type B (GABAB) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, central nervous system side-effects limit its use. Lesogaberan is a novel peripherally acting GABAB agonist, but its effects...

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Bibliographic Details
Main Authors: Huda Badri, Carmen Gibbard, Dimitra Denton, Imran Satia, Bashar Al-Sheklly, Rachel J. Dockry, Kimberley Holt, Kevin McGuiness, Sam Treadway, Peter Whorwell, Lesley Houghton, Augustine Lee, K. Jane Escott, Theresa Lee, Greame Wilkinson, Alison Holt, Brendan J. Canning, Jacky A. Smith
Format: Article
Language:English
Published: European Respiratory Society 2022-03-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/8/1/00546-2021.full

Internet

http://openres.ersjournals.com/content/8/1/00546-2021.full

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