Combinatorial Use of Both Epigenetic and Non-Epigenetic Mechanisms to Efficiently Reactivate HIV Latency

Combinatorial Use of Both Epigenetic and Non-Epigenetic Mechanisms to Efficiently Reactivate HIV Latency

The persistence of latent HIV provirus pools in different resting CD4+ cell subsets remains the greatest obstacle in the current efforts to treat and cure HIV infection. Recent efforts to purge out latently infected memory CD4+ T-cells using latency-reversing agents have failed in clinical trials. T...

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Bibliographic Details
Main Authors: Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Mudit Tyagi
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
epigenetic
non-epigenetic
HIV latency
reactivation
transcription
Online Access:https://www.mdpi.com/1422-0067/22/7/3697

Internet

https://www.mdpi.com/1422-0067/22/7/3697

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