In vitro hepatic biotransformation of the algal toxin pectenotoxin-2

We have investigated the in vitro metabolism of pectenotoxin-2 (PTX-2) using primary hepatocytes from Wistar rats in suspension. Purified PTX-2 was rapidly metabolized. Two major and several minor oxidized PTX-2 metabolites were formed, none of which had retention times corresponding to PTX-1, -11,...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Morten Sandvik, Christopher O. Miles, Alistair L. Wilkins, Christiane Fæste
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: Elsevier 2020-06-01
Σειρά:Toxicon: X
Διαθέσιμο Online:http://www.sciencedirect.com/science/article/pii/S2590171020300096