In vitro hepatic biotransformation of the algal toxin pectenotoxin-2

In vitro hepatic biotransformation of the algal toxin pectenotoxin-2

We have investigated the in vitro metabolism of pectenotoxin-2 (PTX-2) using primary hepatocytes from Wistar rats in suspension. Purified PTX-2 was rapidly metabolized. Two major and several minor oxidized PTX-2 metabolites were formed, none of which had retention times corresponding to PTX-1, -11,...

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Bibliografiske detaljer
Main Authors:	Morten Sandvik, Christopher O. Miles, Alistair L. Wilkins, Christiane Fæste
Format:	Article
Sprog:	English
Udgivet:	Elsevier 2020-06-01
Serier:	Toxicon: X
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2590171020300096

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