Safety and Immunogenicity of Recombinant <i>Bacille Calmette-Guérin</i> Strain VPM1002 and Its Derivatives in a Goat Model

Safety and Immunogenicity of Recombinant <i>Bacille Calmette-Guérin</i> Strain VPM1002 and Its Derivatives in a Goat Model

A more effective vaccine against tuberculosis than <i>Bacille Calmette-Guérin</i> (BCG) is urgently needed. BCG derived recombinant VPM1002 has been found to be more efficacious and safer than the parental strain in mice models. Newer candidates, such as VPM1002 Δ<i>pdx1</i>...

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Bibliographic Details
Main Authors: Julia Figl, Heike Köhler, Nadine Wedlich, Elisabeth M. Liebler-Tenorio, Leander Grode, Gerald Parzmair, Gopinath Krishnamoorthy, Natalie E. Nieuwenhuizen, Stefan H. E. Kaufmann, Christian Menge
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
VPM1002
<i>Bacille Calmette-Guérin</i>
immune response
tuberculosis vaccine
goat model
Online Access:https://www.mdpi.com/1422-0067/24/6/5509

Internet

https://www.mdpi.com/1422-0067/24/6/5509

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