Mutational biases favor complexity increases in protein interaction networks after gene duplication

Abstract Biological systems can gain complexity over time. While some of these transitions are likely driven by natural selection, the extent to which they occur without providing an adaptive benefit is unknown. At the molecular level, one example is heteromeric complexes replacing homomeric ones fo...

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Bibliographic Details
Main Authors: Angel F Cisneros, Lou Nielly-Thibault, Saurav Mallik, Emmanuel D Levy, Christian R Landry
Format: Article
Language:English
Published: Springer Nature 2024-03-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.1038/s44320-024-00030-z