Purification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging

Purification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging

Summary: Endocrine cells employ regulated exocytosis of secretory granules to secrete hormones and neurotransmitters. Secretory granule exocytosis depends on spatiotemporal variables such as proximity to the plasma membrane and age, with newly generated granules being preferentially released. Despit...

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Bibliographic Details
Main Authors: Martin Neukam, Pia Sala, Andreas-David Brunner, Katharina Ganß, Alessandra Palladini, Michal Grzybek, Oleksandra Topcheva, Jovana Vasiljević, Johannes Broichhagen, Kai Johnsson, Thomas Kurth, Matthias Mann, Ünal Coskun, Michele Solimena
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724001645

Internet

http://www.sciencedirect.com/science/article/pii/S2211124724001645

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