PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site

PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site

After spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, forming lipid-laden foamy macrophages. To understand their role in the cellular pathology of SCI, investigation of the foamy macrophage phenotype in vitro revealed a pro-inflammator...

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Bibliographic Details
Main Authors: Christine B. Ryan, James S. Choi, Brian Kang, Seth Herr, Claudia Pereira, Carlos T. Moraes, Hassan Al-Ali, Jae K. Lee
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Neurobiology of Disease
Subjects:
Foamy macrophages
Spinal cord injury
Neuroinflammation
Autophagy
PI3K
Lipids
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123003868

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http://www.sciencedirect.com/science/article/pii/S0969996123003868

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