Inhibition of the Glycine Receptor alpha 3 Function by Colchicine

Inhibition of the Glycine Receptor alpha 3 Function by Colchicine

Colchicine is a plant alkaloid that is widely used as a therapeutic agent. It is widely accepted that colchicine reduces the production of inflammatory mediators mainly by altering cytoskeleton dynamics due to its microtubule polymerization inhibitory activity. However, other lines of evidence have...

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Bibliographic Details
Main Authors: Carola Muñoz-Montesino, Carlos F. Burgos, Cesar O. Lara, Camila R. Riquelme, David Flaig, Victoria P. San Martin, Luis G. Aguayo, Jorge Fuentealba, Patricio A. Castro, Leonardo Guzmán, Gonzalo E. Yévenes, Gustavo Moraga-Cid
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
glycine receptor
antagonist
colchicine
pentameric ligand-gated ion channel
pain
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01143/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.01143/full

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