Molecular dynamics simulation and experimental study of the surface-display of SPA protein via Lpp-OmpA system for screening of IgG

Molecular dynamics simulation and experimental study of the surface-display of SPA protein via Lpp-OmpA system for screening of IgG

Abstract Staphylococcal protein A (SpA) is a major virulence factor of Staphylococcus aureus. S. aureus is able to escape detection by the immune system by the surface display of protein A. The SpA protein is broadly used to purify immunoglobulin G (IgG) antibodies. This study investigates the fusio...

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Bibliographic Details
Main Authors: M. Vahed, F. Ramezani, V. Tafakori, V. S. Mirbagheri, A. Najafi, G. Ahmadian
Format: Article
Language:English
Published: SpringerOpen 2020-09-01
Series:AMB Express
Subjects:
Protein A–IgG interaction
Surface-displayed OmpA
Protein interaction
Molecular dynamics
Online Access:http://link.springer.com/article/10.1186/s13568-020-01097-1

Internet

http://link.springer.com/article/10.1186/s13568-020-01097-1

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