The ECM and tissue architecture are major determinants of early invasion mediated by E-cadherin dysfunction

The ECM and tissue architecture are major determinants of early invasion mediated by E-cadherin dysfunction

Abstract Germline mutations of E-cadherin cause Hereditary Diffuse Gastric Cancer (HDGC), a highly invasive cancer syndrome characterised by the occurrence of diffuse-type gastric carcinoma and lobular breast cancer. In this disease, E-cadherin-defective cells are detected invading the adjacent stro...

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Main Authors: Soraia Melo, Pilar Guerrero, Maurício Moreira Soares, José Rafael Bordin, Fátima Carneiro, Patrícia Carneiro, Maria Beatriz Dias, João Carvalho, Joana Figueiredo, Raquel Seruca, Rui D. M. Travasso
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05482-x

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https://doi.org/10.1038/s42003-023-05482-x

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