Fangchinoline diminishes STAT3 activation by stimulating oxidative stress and targeting SHP-1 protein in multiple myeloma model

Fangchinoline diminishes STAT3 activation by stimulating oxidative stress and targeting SHP-1 protein in multiple myeloma model

Introduction: The development of cancer generally occurs as a result of various deregulated molecular mechanisms affecting the genes that can control normal cellular growth. Signal transducer and activator of transcription 3 (STAT3) pathway, once aberrantly activated can promote carcinogenesis by re...

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Bibliographic Details
Main Authors: Young Yun Jung, In Jin Ha, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Journal of Advanced Research
Subjects:
Fangchinoline
STAT3
Apoptosis
Multiple myeloma
ROS
GSH
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123221000576

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http://www.sciencedirect.com/science/article/pii/S2090123221000576

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