The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation

The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation

NSIAD is a rare X-linked condition, caused by activating mutations in the <i>AVPR2</i> gene coding for the vasopressin V2 receptor (V2R) associated with hyponatremia, despite undetectable plasma vasopressin levels. We have recently provided in vitro evidence that, compared to V2R-wt, exp...

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Bibliographic Details
Main Authors: Marianna Ranieri, Maria Venneri, Tommaso Pellegrino, Mariangela Centrone, Annarita Di Mise, Susanna Cotecchia, Grazia Tamma, Giovanna Valenti
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
vasopressin
V2R
NSIAD
AQP2
Rho kinase (ROCK)
Online Access:https://www.mdpi.com/2073-4409/9/6/1354

Internet

https://www.mdpi.com/2073-4409/9/6/1354

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