TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein

TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein

Members of the tripartite motif (TRIM)-containing protein family play crucial roles in regulating immune system responses. The TRIM38 protein regulates host innate immunity and directly degrades some viral proteins through its E3 ubiquitin ligase activity. This study demonstrated that Zika virus (ZI...

Full description

Bibliographic Details
Main Authors: Jing He, Yulian Kuang, Kui Xu, Rong Huang, Xiaoyao Yang, Liyao Deng, Xiaojuan Feng, Yang Ren, Jian Yang, Lei Yuan
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Viruses
Subjects:
Zika virus
TRIM38
NS3 protein
antiviral activity
ubiquitination
Online Access:https://www.mdpi.com/1999-4915/17/2/199

Internet

https://www.mdpi.com/1999-4915/17/2/199

Similar Items