Microwave-assisted Phospha-Michael addition reactions in the 13α-oestrone series and in vitro antiproliferative properties

Microwave-assisted Phospha-Michael addition reactions in the 13α-oestrone series and in vitro antiproliferative properties

Microwave-assisted phospha-Michael addition reactions were carried out in the 13α-oestrone series. The exocyclic 16-methylene-17-ketones as α,β-unsaturated ketones were reacted with secondary phosphine oxides as nucleophilic partners. The addition reactions furnished the two tertiary phosphine oxide...

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Bibliographic Details
Main Authors: Erzsébet Mernyák, Sándor Bartha, Lili Kóczán, Rebeka Jójárt, Vivien Resch, Gábor Paragi, Máté Vágvölgyi, Attila Hunyadi, Bella Bruszel, István Zupkó, Renáta Minorics
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
phospha-michael addition
13α-oestrone
α,β-unsaturated ketone
antiproliferative effect
tumour selectivity
Online Access:http://dx.doi.org/10.1080/14756366.2021.1963241

Internet

http://dx.doi.org/10.1080/14756366.2021.1963241

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