Glial Gap Junction Pathology in the Spinal Cord of the 5xFAD Mouse Model of Early-Onset Alzheimer’s Disease

Glial Gap Junction Pathology in the Spinal Cord of the 5xFAD Mouse Model of Early-Onset Alzheimer’s Disease

Gap junctions (GJs) are specialized transmembrane channels assembled by two hemi-channels of six connexin (Cx) proteins that facilitate neuroglial crosstalk in the central nervous system (CNS). Previous studies confirmed the crucial role of glial GJs in neurodegenerative disorders with dementia or m...

Full description

Bibliographic Details
Main Authors: Maria Pechlivanidou, Ioanna Kousiappa, Stella Angeli, Irene Sargiannidou, Andreas M. Koupparis, Savvas S. Papacostas, Kleopas A. Kleopa
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
gap junctions
neurodegeneration
5xFAD
spinal cord
motor deficits
Online Access:https://www.mdpi.com/1422-0067/23/24/15597

Internet

https://www.mdpi.com/1422-0067/23/24/15597

Similar Items