<italic toggle="yes">Cryptococcus neoformans</italic> Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress

<italic toggle="yes">Cryptococcus neoformans</italic> Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress

ABSTRACT Copper (Cu) ions serve as catalytic cofactors to drive key biochemical processes, and yet Cu levels that exceed cellular homeostatic control capacity are toxic. The underlying mechanisms for Cu toxicity are poorly understood. During pulmonary infection by the fungal pathogen Cryptococcus ne...

Full description

Bibliographic Details
Main Authors: Sarela Garcia-Santamarina, Marta A. Uzarska, Richard A. Festa, Roland Lill, Dennis J. Thiele
Format: Article
Language:English
Published: American Society for Microbiology 2017-11-01
Series:mBio
Subjects:
ABC transporters
copper toxicity
Cryptococcus neoformans
Fe-S cluster
copper ionophores
metalloproteins
Online Access:https://journals.asm.org/doi/10.1128/mBio.01742-17

Internet

https://journals.asm.org/doi/10.1128/mBio.01742-17

Similar Items