Anaerobic Fungal Mevalonate Pathway Genomic Biases Lead to Heterologous Toxicity Underpredicted by Codon Adaptation Indices

Anaerobic Fungal Mevalonate Pathway Genomic Biases Lead to Heterologous Toxicity Underpredicted by Codon Adaptation Indices

Anaerobic fungi are emerging biotechnology platforms with genomes rich in biosynthetic potential. Yet, the heterologous expression of their biosynthetic pathways has had limited success in model hosts like <i>E. coli</i>. We find one reason for this is that the genome composition of anae...

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Bibliographic Details
Main Authors: Ethan T. Hillman, Elizabeth M. Frazier, Evan K. Shank, Adrian N. Ortiz-Velez, Jacob A. Englaender, Kevin V. Solomon
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Microorganisms
Subjects:
anaerobic fungi
mevalonate pathway
isoprenoid biosynthesis
heterologous expression
codon usage
codon optimization
Online Access:https://www.mdpi.com/2076-2607/9/9/1986

Internet

https://www.mdpi.com/2076-2607/9/9/1986

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